Raso et al. connected the loss of integrin αv in B cells with a loss of RUBICON-dependent noncanonical autophagy in B cells (75); however, these studies did not look at global Rubicon–/– phenotypes in the setting of autoimmunity and failed to convincingly demonstrate that RUBICON was necessary for LC3β-II formation in B cells (Figure 5; ref. 60). The gene discussed is RUBCN; the disease is Autoimmunity.