Strikingly, mice deficient in components implicated in canonical autophagy only, i.e., Unc-51–like kinase 1 (ULK1) and FAK family kinase-interacting protein of 200 kDa (FIP200), did not develop systemic autoimmunity with age, suggesting that LAP but not canonical autophagy is required to prevent autoimmunity (38). This evidence concerns the gene RB1CC1 and Autoimmunity.