The other pathways culminated into 3 distinct Tex subpopulations with coexpression of CD39 and CD103, suggestive of tumor reactivity: pathway 2, CD8_Tem cells toward CD8_Tex1 subpopulation (NKG7, GZMK, GZMA); pathway 3, CD8_Trm cells toward CD8_Tex2 subpopulation (KLRB1, IGFLR1, CD161hi); or pathway 4, IELs toward CD8_Tex3 subpopulation (CXCR6, GNLY, CCL5, CD161+). Here, IGFLR1 is linked to neoplasm.