Cells within the CD4_Stim2.Th17.1 cluster expressed genes associated with regulatory function (IL10, ITGA2) (46, 47), whereas cells within the CD4_Stim2.Th17.2 cluster expressed proinflammatory effectors (IFNG, IL23R, PRF1), described to be produced by pathogenic Th17 cells in autoimmunity (Supplemental Figure 5F) (48). Here, PRF1 is linked to Autoimmunity.