OSMR and neoplasm: As we previously observed that fibroblasts were the cell population with higher levels of OSMR within the tumor (Figures 3 and 4 and Supplemental Figures 4 and 5), we performed complementary in vitro and in vivo experiments to assess the effect of OSMR activation in mammary CAFs and normal fibroblasts derived from human breast tumors and reduction mammoplasty surgeries, respectively (28).