In addition, after coculture with B16 cells, Cpt1a-knockdown Tc9 cells were more vulnerable to tumor-induced decreases in mitochondrial activity and increases in lipid peroxidation and ferroptosis than control Tc9 cells (Figure 4O), while Cpt1a overexpression (Supplemental Figure 6H) effectively rescued Tc9 cells from tumor-induced decreases in mitochondrial activity and increases in lipid peroxidation and ferroptosis (Figure 4P). The gene discussed is CPT1A; the disease is neoplasm.