ACE and hypertensive disorder: With the exception of the so-called decapitated hypertension, characterised by a reduction in blood pressure values independent of treatment and secondary to an overt reduction in ventricular function [6], the contribution of “cardiac performance” to the equation can generally be neglected and hypertension be treated with agents targeting its volume (mainly diuretics) or vasoconstriction (e.g. calcium channel blockers, ACE-inhibitors, AT1-receptor blockers) components, or a combination of them.