Chronic liver disease (CLD) includes pathologies arising from various aetiologies such as viral hepatitis (B and C), alcohol-related liver disease (ARLD), non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH), haemochromatosis, autoimmune disease, Wilson’s disease and alpha-1 anti-trypsin deficiency [1]. Here, PSMA6 is linked to metabolic dysfunction-associated steatohepatitis.