Manifest remarkable effects in the cure of cancer, mainly presenting in restraining cancer proliferation [12], invasion [13], migrate [14] and transfer [15], etc. The present study elucidated how Rop constrains the growth and self-renewal of GBM stem cells via repressing zinc finger Asp-His-His-Cys-type palmitoyltransferase 15 (ZDHHC15)-mediated palmitoylation of GP130 [16]. Here, ZDHHC15 is linked to cancer.