We found that FMRP S499 phosphorylation, which leads to FMRP‐mediated translational suppression, was 1.4‐fold elevated by a chronic exposure to hypercholesterolemia, whereas FMRP protein and Fmr1 mRNA expression levels remained unchanged (Fig 1D; Appendix Fig S1C and D). This evidence concerns the gene FMR1 and Hypercholesterolemia.