ERN1 and atherosclerosis: While characterizing the impact of IRE1 kinase activity and it’s here proposed kinase substrate, FMRP, on macrophage functions, our current study revealed a role for an “IRE1‐FMRP signaling axis” in the regulation of macrophage cholesterol trafficking and efferocytosis, which are among the primary cellular mechanisms that can regress atherosclerosis (Fig 7).