FMR1 and atherosclerosis: Although these findings foreshadowed a role of FMRP in the regulation of cholesterol homeostasis (Tuomisto et al, 2003; Darnell et al, 2011; Ascano et al, 2012), FMRP’s contribution to atherosclerosis was not investigated prior to this study, perhaps because Fmr1 lies on the X chromosome and most genome‐wide association studies in humans focus on variants on autosomal chromosomes excluding sex chromosomes.