To further digest which MAPK signalling is response to HO‐3867 induced apoptosis, we next measure apoptotic signalling in HO‐3867‐treated human oral cancer cells SCC‐9 and HSC‐3 cells under inhibitions of ERK1/2, JNK1/2 or p38. This evidence concerns the gene MAPK3 and lip and oral cavity carcinoma.