AKT1 and pancreatic insulinoma: Chang et al (2016) showed that GLP‐1 suppressed methylglyoxal (MG)‐induced apoptosis in a rat insulinoma cell line (RINm5F) by improving mitochondrial function and activating PKA and PI3K/Akt signaling, thereby causing Akt phosphorylation and subsequent inhibition of the cleavage (ie, activation) of pro‐apoptotic caspase‐3.