In view of the current relevant molecular dynamic results, it led us to predict that in case of the FMF patients harboring Lys671Met, Ser703Ile, and Ala744Ser variants, hyperactivation of NF-kB and increased IkB-α proteolysis might occur and hence the colchicine treatment is preferred to higher its doses than patients with negative Lys671Met, Ser703Ile, and Ala744Ser. Here, NFKB1 is linked to familial Mediterranean fever.