TP53 and neoplasm: It has been demonstrated that the anticancer activity of quercetin is facilitated via the activation of the adenosine monophosphate (AMP)-activated protein kinase (AMPK) pathway, suppression of the phosphoinositide 3-kinase/PI3K/AKT/mammalian target of rapamycin/NF-κB pathway, upregulation of p53 activation, and the apoptosis pathway, and when used with other chemotherapeutic agents, quercetin can achieve tumor-improving results by enhancing apoptosis and reducing side effects [45].