In order to further study the mechanism of SD affecting the growth of tumor cells, in the network pharmacology part, we have observed that the epidermal growth factor receptor signaling pathway is an important medium for SD affecting lung adenocarcinoma, and in the in vitro part, we have verified the mechanism of SD affecting the epidermal growth factor receptor-related pathways, focusing on EGFR/JAK/STAT and EGFR/PI3K/AKT. This evidence concerns the gene AKT1 and lung adenocarcinoma.