TP53 and neoplasm: p53 can also promote antitumor microenvironment to inhibit tumor occurrence.By releasing related factors, the hepatic stellate cell expressing p53 made macrophage polarization tend to M1 state, which can inhibit the occurrence of tumor, while the factors secreted by p53 deficient stellate cells stimulated macrophage polarization into the M2 state and enhanced the proliferation of precancerous cell [42].