Also, we added experimental validation, specifically, we collected tissues from five early IDD patients (III) and five advanced IDD patients (V) from The Third People's Hospital of Nanning and evaluated the expression differences of SIRT7, NTRK2, and CHI3L1 using RT-PCR, and as expected, they had a trend of higher expression in advanced IDD patients, with CHI3L1 and NTRK2 having a significant expression difference (Supplementary Figure S1). Here, SIRT7 is linked to intervertebral disk degenerative disorder.