Jinwen Zhu et al. identified several lncRNA/circRNA-miRNA-mRNA interaction axes (MALAT1/hsa_circRNA_102348-hsa-miR-185-5p- TGFB1/FOS, MALAT1-hsa-miR-155-5p-HIF1A, hsa_circRNA_102399-hsa-miR-302a-3p-HIF1A, MALAT1-hsa-miR-519d-3p-MAPK1, and hsa_circRNA_100086-hsa-miR-509-3p-MAPK1), which may be crucial for the treatment of IDD [13]. Here, MAPK1 is linked to intervertebral disk degenerative disorder.