PARK7 and neoplasm: In a previous study, Cao et al.13 reported the integration of DJ-1 in ferroptosis; specifically, these authors identified that the inhibition of DJ-1, both in vivo and in vitro, can effectively enhance the sensitivity of tumor cells to inducers of ferroptosis and that the depletion of DJ-1 plays a role in promoting ferroptosis by destroying the formation of S-adenosine homocysteine hydrolase tetramer and reducing its activity.