Indeed, reprogramming factors, including SRY-box 2 (SOX2), octamer-binding transcription factor 4 (OCT4, also known as POU5F1), Krüppel-like factor 4 (KLF4), and MYC (collectively known as OKSM transcription factors), and chromatin modifiers are required for establishment of iPSCs are associated with cancer generation4,5. The gene discussed is KLF4; the disease is cancer.