To investigate the roles of miR-1181, miR-18b-5p, miR-145-3p, miR-376b-5p, miR-676-3p and miR-718 mimics in combination with metformin on CRC cell death, caspase 3/7 activity was assessed as a marker of apoptosis. Here, CASP3 is linked to colorectal carcinoma.