Compared to non-recurrent patients, new recurrent patients were less married (70.5%), smoked more (15.9%), had higher breast cancer stages (59.1%), poorer cell differentiation (47.7%), larger tumor size (61.9%), less ER-positive status (66.7%), less PR-positive status (44.4%), more chemotherapy (88.9%), and more radiotherapy (80.0%). Here, ESR1 is linked to breast cancer.