IL6 and neoplasm: For the clinical implications of the circCUL2/miR-203a-3p/MyD88/IL6 axis in PDAC patients, we revealed that high levels of circCUL2, MyD88 and IL6 expression in tumor tissues are associated with poor prognosis in patients with pancreatic cancer, and high miR-203a-3p expression indicates better OS and DFS in PDAC patients.