Recently, our team reported that circBFAR promotes the progression of PDAC via the miR-34b-5p/MET/Akt axis and that circNFIB1 inhibits lymphangiogenesis and lymphatic metastasis via the miR-486-5p/PIK3R1/VEGF-C axis in pancreatic cancer [20, 21]. The gene discussed is PIK3R1; the disease is familial pancreatic carcinoma.