CTLA4 and cancer: To date, ICP-targeting drugs such as ipilimumab, which targets cytotoxic T-lymphocyte-associated protein 4 (CTLA-4); nivolumab, which targets programmed cell death protein 1 (PD-1); and atezolizumab, which targets PD-1 ligand 1 (PD-L1) have been shown to be effective cancer immunotherapies, especially in solid malignancies [18, 20–23].