CD8A and melanoma: In addition, EVs purified from DCs loaded with antigens and matured with the Toll-like receptor 3 (TLR3) ligand poly (I:C) strongly stimulated the proliferation of CD8+ and CD4+ T cells and recruited CD8+ T cells and natural killer (NK) cells to tumors, thereby enhancing the antitumor functions of the EVs and inhibiting melanoma growth [164].