In a Cox regression model adjusted for the above covariates, compared to veterans with an eGFR of ≥90 ml/min/1.73 m2, veterans with stage 3A (hazards ratio (HR) 1.31, 95% CI 1.28 to 1.33), stage 3B (HR 1.59, 95% CI 1.56 to 1.63) and stage 4/5 (HR 1.80, 95% CI 1.74 to 1.87) CKD had substantially higher new insulin use during follow-up (Fig. 2, Panel B). The gene discussed is INS; the disease is chronic kidney disease.