Using those not on insulin with eGFR ≥90 ml/min/1.73 m2 as the reference group, those on insulin with eGFR < 30 ml/min/1.73 m2 had the highest risk of hypoglycemia (in the entire analytic cohort HR 5.62, 95% CI 5.19 to 6.09 and in the propensity score matched cohort HR 5.24, 95% CI 4.62 to 5.93) with the other groups having intermediate risks (Fig. 5, panels A and B). The gene discussed is INS; the disease is Hypoglycemia.