In a multivariable Cox regression model in the propensity score matched cohort (N = 305,570), the corresponding hazard ratios for hypoglycemic events for insulin use (HR 2.34, 95% CI 2.24 to 2.44) and more advanced CKD (HR2.28, 95% 2.07 to 2.51) were similar to that observed in the entire cohort (Fig. 4, panel B). The gene discussed is INS; the disease is chronic kidney disease.