The results suggested that POLD1 expression was significantly positively correlated with TMB in ACC, bladder urothelial carcinoma (BLAC), breast invasive carcinoma (BRCA), glioblastoma multiforme (GBM), KICH, LGG, lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), MESO, ovarian serous cystadenocarcinoma (OV), pancreatic adenocarcinoma (PAAD), SARC, skin cutaneous melanoma (SKCM), stomach adenocarcinoma (STAD), testicular germ cell tumor (TGCT), thyroid carcinoma (THCA), uterine corpus endometrial carcinoma (UCEC), and uterine carcinosarcoma (UCS) (Supplementary Figure S3C). The gene discussed is POLD1; the disease is cutaneous melanoma.