After PSM accounting for unbalanced factors, including KPS score, EGFR-TKI generations and baseline bone metastasis, the iTTP of patients with common EGFR mutations was still longer than that of uncommon mutations (uncommon vs. 19del, 23.6 months vs. 34.7 months, p = 0.018; uncommon vs. L858R, 23.6 months vs. NR, p = 0.032; Fig. 4C-D). Here, EGFR is linked to bone metastasis.