The mechanism of EBV hepatitis is thought to be that EBV infected and activated CD8 + T-cells accumulate in the liver and the products of the EBV-infected CD8 + T cells or infiltrating cytotoxic T lymphocytes were interferon-γ, tumor necrosis factor and Fas ligand, which can destroy hepatocytes [20–23]. Here, CD8A is linked to hepatitis A virus infection.