Similar studies have demonstrated that the overexpression of Nrf2 and antioxidant enzymes (HO-1 and SOD) by curcumin treatment protects against different events of cellular damage due to oxidative stress, such as in models of cardiac ischemia, glomerulonephritis, and neuronal damage [15, 27, 22]. This evidence concerns the gene HMOX1 and glomerulonephritis.