Next, animal studies were carried out in mice with metabolic syndrome and results indicated that the dual‐core system for delivery of probiotics reduced the expression of two inflammatory cytokines in the intestine (IL‐6 and IL‐10; Figure 9b), and immunostaining of important intestinal barrier proteins (claudin‐1 and occludin) showed decreased intestinal hyperpermeability (Figure 9c). The gene discussed is IL6; the disease is metabolic syndrome.