CD8A and cancer: Our data confirms the association between higher mortality and hematological malignant neoplasms, consistent with UK primary care data.20 The COVID-19 immunological signature and postviral clearance immune state of patients with solid cancer is similar to the signature of people with COVID-19 infection but without cancer.21 In contrast, patients with hematological cancer and COVID-19 have much less immune activation, high levels of CD8+ T-cell exhaustion, severe B cell cytopenia.