PLOD2 and idiopathic pulmonary fibrosis: We then performed RNA in situ hybridisation upon IPF lung tissue, with semi-quantitative analysis (Supplementary file 1a); the results showed that the greatest expression of LOXL2 and PLOD2 in IPF tissue was by mesenchymal cells within fibroblast foci, and that LOXL2 and PLOD2 are co-expressed within the same cells (Figure 1h) within areas of fibrillar collagen deposition (Figure 1—figure supplement 1f-h).