To investigate common regulators of PLOD2 and LOXL2 in lung fibrosis, we studied their expression in primary human lung fibroblasts over a 72-hr time course following activation (Figure 2—figure supplement 1a) of transforming growth factor beta (TGFβ), epidermal growth factor (EGF), hypoxia inducible factors (HIF) or Wnt signalling pathways, each of which have been implicated in fibrogenesis (Richeldi et al., 2017; Yao et al., 2019; Martin-Medina et al., 2018; Königshoff et al., 2008; Yue et al., 2010; Bodempudi et al., 2014; Hill et al., 2019a; Yao et al., 2021; Zhou et al., 2021). Here, PLOD2 is linked to pulmonary fibrosis.