As LOXL2 is processed intracellularly before being extracellularly secreted, we therefore investigated whether increased secretion of LOXL2 was occurring; this identified that under conditions with HIF stabilisation LOXL2 secretion was increased in both IPF fibroblasts (Figure 4d) and control fibroblasts (Figure 4—figure supplement 1). The gene discussed is LOXL2; the disease is idiopathic pulmonary fibrosis.