IL18 and acute respiratory distress syndrome: In cecal ligation and puncture (CLP)-induced ALI, the expression of pyroptosis-related proteins, such as NLRP3, cysteine-containing aspartate-specific protease 1 (caspase-1), and GSDMD, and the levels of related inflammatory cytokines interleukin-1β (IL-1β) and interleukin-18 (IL-18) were upregulated [14].