In another study, the same laboratory showed that BPI fold-containing family B member 3 (BPIFB3), an autophagy regulator that negatively controls enterovirus replication (521), functions as a positive regulator of DENV and ZIKV infection and that its depletion inhibits the formation of viral replication organelles (522). Here, BPIFB3 is linked to Zika virus infectious disease.