HDAC9 and neoplasm: We also found that GCJ-490A and co-treated xenografts, compared with those treated with vehicle, showed lower c-Met protein expression in tumor tissues, on the basis of IHC staining (Figure 2I), and up-regulation of acetylated histone H3 lysine 9 (H3K9-Ac) (Supplementary Figure S1B), thus indicating HDAC inhibition in xenografts.