In this respect, neurofibromin has previously been reported within the nucleus of neurons and glia (Daston et al., 1992; Koliou et al., 2016; Li et al., 2001), as well as in the nucleus of breast cancer cells (Dischinger et al., 2018; Zheng et al., 2020), as a result of interactions with Ran and CRM-1 (also known as XPO1) (Zheng et al., 2020). The gene discussed is XPO1; the disease is breast cancer.