While heterozygosity for a germline NF1 mutation has biological consequences, such as learning and attention deficits, and autism (Bajenaru et al., 2001; Costa et al., 2002, 2001; Cui et al., 2008; Li et al., 2005; Maloney et al., 2018; Molosh et al., 2014; Molosh and Shekhar, 2018; Omrani et al., 2015; Silva et al., 1997), a single NF1 mutation is not sufficient for tumor formation. This evidence concerns the gene NF1 and neoplasm.