PofOm enrichment at SoC-CpGs is driven by a large PofOm region spanning 6 CpGs on chr15 at IGF1R (Supplementary file 1d); along with two singleton PofOm SoC-CpGs, one on chr18 close to PARD6G and the other in the Prader-Willi syndrome-associated imprinted region neighbouring MAGEL2, also on chr15. The gene discussed is UBXN11; the disease is Prader-Willi syndrome.