A similarly modest DNAm change at a locus in the POMC gene that is associated with SoC in blood has been linked to obesity risk in German children and adults (Kühnen et al., 2016; Kuehnen et al., 2012), and to differential TF binding and differences in POMC expression (Kuehnen et al., 2012). This evidence concerns the gene UBXN11 and obesity due to melanocortin 4 receptor deficiency.