CD47 and prostate neoplasm: In this context, it has been demonstrated that sEVs isolated from bone marrow-derived mesenchymal stem cells (MSC-sEVs) are stable in circulation due to the presentation of CD47 on their surface.35 Therefore, future in vitro and in vivo studies aiming at inhibiting of the αVβ6 integrin in prostate tumors could potentially be optimized by using MSC-sEVs.