The main goal of surgery was to achieve negative margins, which failed in some cases due to the fact that ES spreading locally through synovial spaces, along nerves, vessels, and bones.19 Nevertheless, 5-year RFS was estimated with 80.4%, which is not different from other sarcoma subtypes.15,20 But it should be noted that with local relapse, the possibility of further successful limb-sparing surgery reduces due to typical ES growth, lack of reserve of radiation therapy, and no pathological response of TM-ILP. This evidence concerns the gene XIAP and sarcoma.