Recent studies showed that ASCT2‐mediate uptake of exogenous glutamine can maintain TICs self‐renewal in pancreatic cancer[17] and exogenous glutamine can maintain TICs self‐renewal by a redox‐mediated mechanism mediated by β‐catenin in non‐small cell lung carcinoma and pancreatic cancer.[18] These studies indicate that the survival and self‐renewal of tumor initiating cells depend on glutamine. This evidence concerns the gene SLC1A5 and pancreatic neoplasm.