AKT1 and cancer: Glutamine has been found to activate mTORC1, regulate translation and autophagy to coordinate cell growth and proliferation.[29, 40] While Rictor, a key component of the mTORC2 complex,[41] directly phosphorylates AKT/PKB at Ser473,[31] which is required for cell survival and tumor progression in various cancers[42, 43] and suggests that mTORC2 are also involved in the regulation of cancer biology.