Serum ESR (p = 0.0013), CRP (p = 0.0067), LDH (p = 0.0004) and CPK (p = 0.0077) levels were higher in severe COVID-19 patients at baseline than in mild patients whilst baseline levels of all but CPK (p = 0.1193) were also higher in moderate patients compared with mild patients (Table 2). This evidence concerns the gene ESR1 and COVID-19.