We found 21 potential driver genes (KRAS, TSPOAP1, C6, CCDC169-SOHLH2, DNAH9, MAP7D1, NCKAP5, NRXN1, PREX2, SMG1, TNKS1BP1, TTN, ABCB4, ALK, ATXN1, ASTN2, C2ORF16, CARD6, KNL1, CENPF, CLCNKA) using Fisher's exact test, which were significantly enriched in the recurrence-free group and were negatively associated with gastric cancer recurrence (Table 3). The gene discussed is SOHLH2; the disease is gastric cancer.