LDLR and Hypercholesterolemia: Our data showed that depleting ApoC3 by CRISPR/Cas9 gene editing significantly reduced circulating TG and TC levels in LDLR−/− hamsters on standard laboratory diet, but only lowered plasma TG concentration in HCHF diet-fed female LDLR−/− hamsters without affecting severe refractory hypercholesterolemia.