APOC3 and metabolic syndrome: Previously, using CRISPR/Cas9 editing our group deleted the Apoc3 gene from the Syrian golden hamster model that replicates human metabolic features, and we found that lack of ApoC3 significantly decreased plasma TG and total cholesterol (TC) levels, meanwhile increased high-density lipoprotein cholesterol (HDL-C) in hamsters fed with high-cholesterol/high-fat (HCHF) diet (9), suggesting that ApoC3 deficiency ameliorates diet-induced combined dyslipidemia.