APOC3 and Hypercholesterolemia: However, in agreement with the observations from the clinical trials, whether the beneficial effect of lacking ApoC3 relies on the presence of low-density lipoprotein receptor (LDLR) and whether ApoC3 inhibition can be applied for the treatment of severe refractory hypercholesterolemia and atherosclerosis due to LDLR deficiency still needs to be elucidated.