By analyzing each ligand-receptor pair of THBS signaling between macrophages and SMCs, we identified that Thbs1-Sdc4 was the most elevated pathway sent from Maph-2 to SMCs (especially synthetic SMC-2), and that Thbs1-Cd47 signaling sent from SMC-2 to macrophages (especially pro-inflammatory Maph-2) was decreased by AAA. Here, SDC4 is linked to triple-A syndrome.