Following adjustment for gender, age and multiplicity, four proteins (polymeric immunoglobulin receptor (PIR), neurocan core protein (NCP), vesicular overexpressed-in-cancer pro-survival protein (Ves), and insulin-like growth factor binding protein 3 (IGFBP3) remained significantly associated with the presence of RFs only, 1 [brevican core protein (BCP)] with the presence of CAD only, and 3 proteins [coiled-coil domain-containing protein 126 (C-C126), extracellular superoxide dismutase [Cu-Zn] (SOD), and renin] with the presence of both RFs and CAD. The gene discussed is BCAN; the disease is coronary artery disorder.