By this analysis, subjects with both high Apo CIII and CHA2DS2-VASc score had the highest risk of ischemic stroke/TIA as compared with those with both low Apo CIII and CHA2DS2-VASc score who had the lowest risk of cerebral ischemic events, while subjects with either low Apo CIII/high score or high Apo CIII/low score showed an intermediate risk (Figure 3). The gene discussed is APOC3; the disease is ischemic stroke.