High Apo CIII levels remained associated with ischemic stroke/TIA by including progressively potential confounding factors in the regression models, like age, sex, CAD, AF, diabetes, hypertension, plasma lipids and apolipoproteins, and CHA2DS2-VASc score (Table 3), and even including all these parameters into a Cox regression model with backward stepwise selection of variables (HR 5.22 with 95%CI 1.43–19.01). This evidence concerns the gene APOC3 and hypertensive disorder.