AQP10 was also found expressed in human adipocytes and was proposed to represent an alternative pathway to AQP7 for glycerol efflux from adipose tissue (Laforenza et al., 2013), stimulated by the decreased pH observed during lipolysis (Gotfryd et al., 2018), assuring the maintenance of normal or low glycerol contents inside the adipocyte and protecting humans from obesity. Here, AQP7 is linked to obesity due to melanocortin 4 receptor deficiency.