AQP3-facilitated glycerol transport generates ATP and mediates the growth and survival of tumor cells (Verkman et al., 2014) and, additionally, AQP3 ability to permeate H2O2 may promote tissue inflammation by increasing reactive oxygen species in macrophages (Hara-Chikuma et al., 2020) and contribute to the setting of inflammatory response (da Silva et al., 2020b; da Silva and Soveral, 2021). Here, AQP3 is linked to neoplasm.