Additionally, in a model of non-alcoholic fatty liver disease (NAFLD), AQP9 overexpression resulted in increased intracellular triglycerides, free fatty acids and glycerol levels, leading to the aggravation of steatosis, and this could be reversed with AQP9 suppression (Wang et al., 2013). The gene discussed is AQP9; the disease is metabolic dysfunction-associated steatotic liver disease.