AQP3 and skin neoplasm: Moreover, when AQP3 is overexpressed, epidermal proliferation is enhanced due to the higher AQP3-mediated glycerol permeability and can result in hyperproliferative skin disorders such as psoriasis and skin tumors (da Silva et al., 2021; Hara-Chikuma and Verkman, 2008a; Verkman et al., 2014).