Additionally, in rats with myocardial infarction (MI), miR-212 overexpression was suggested to downregulate AQP9 mRNA and protein expression through PI3K/AKT signaling pathway activation, thereby exerting its therapeutic effect by reducing cardiomyocytes apoptosis, promoting vascular regeneration and attenuating ventricular remodeling (Ren and Wang, 2018). The gene discussed is AQP9; the disease is myocardial infarction.