Curcumin, a non-flavonoid polyphenol known for its anticancer properties, suppresses EGF-induced AQP3 protein expression upregulation and decreases cell migration in cultured human ovarian cancer cells, with inhibitory effect on EGF-induced EGFR, PI3K/AKT, and MEK/ERK activation. The gene discussed is EGF; the disease is ovarian carcinoma.