AQP7 and obesity due to melanocortin 4 receptor deficiency: 17β-estradiol supplement reversed the AQP7 mRNA and protein expression downregulation and glycerol kinase upregulation in visceral adipose tissue in ovariectomized rats, with no effect on the subcutaneous adipose tissue, suggesting its therapeutic potential to prevent the development of obesity in postmenopausal women (Jin et al., 2017).