AQP3 and constipation disorder: For instance, bisacodyl, a laxative widely used to treat constipation, was reported to decrease AQP3 protein expression in rat colon through activation of macrophages and increased PGE2 secretion and was closely associated with an increase in fecal water content, suggesting that bisacodyl may exert a laxative effect due to AQP3 modulation (Ikarashi et al., 2011).