AQP3 and Chronic constipation: Daiokanzoto administration in rats, a combination of sennoside A and glycyrrhizin, and treatment with a purified resin glycoside fraction from Pharbitis Semen (RFP) on human colonic epithelial cells suppresses AQP3 protein expression accompanied with an increase in fecal water content, indicating that both compounds can exert a laxative effect through AQP3 modulation and could be used for chronic constipation treatment (Kon et al., 2018; Zhu et al., 2019).