The copper(II) analogue of Auphen, [Cu(phen)Cl2] (Cuphen, Figure 5) was also observed to inhibit AQP3, although less potently than Auphen, and to reduce glycerol permeation in AQP3-expressing melanoma (Nave et al., 2016; Pinho et al., 2019) and colon cancer cells (Pinho et al., 2021), leading to anti-proliferative effects and cell migration impairment. This evidence concerns the gene AQP3 and melanoma.