Auphen was also shown to inhibit AQP7 in adipocytes (Madeira et al., 2013; Madeira et al., 2014b) and was used to unveil a role of AQP3 in keratinocytes autophagy (Yu et al., 2021), to suppress growth of hepatocellular carcinoma by downregulating AQP3 (Peng et al., 2016), and to impair cell migration via AQP3 blockage in colonic epithelia (Thiagarajah et al., 2017). The gene discussed is AQP3; the disease is hepatocellular carcinoma.