Considering the role of AQP3-mediated water transport in the airways, increasing AQP3 expression through modulation with corticosteroids as dexamethasone and ambroxol could exert a therapeutic effect on pulmonary diseases with airway hypersecretion through clearance of pulmonary fluid (Tanaka et al., 1997; Ben et al., 2008). Here, AQP3 is linked to lung disorder.