ALS-linked TDP-43 mutations lead to decreased interaction with mRNA, reduced RNP granule dynamics and disrupted axonal transport dynamics (Alami et al., 2014; Ishiguro et al., 2016; Gopal et al., 2017; Endo et al., 2018; Thelen and Kye, 2019), implicating TDP-43’s role in local translation. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.