Interestingly, several RNA-binding proteins involved in neurodegenerative diseases have been implicated in the maintenance of DNA integrity in response to DNA damage, including TDP-43, FUS, hnRNPA1, and Ataxin-2 (Flynn et al., 2011; Skourti-Stathaki and Proudfoot, 2014; Mitra et al., 2019). This evidence concerns the gene TARDBP and neurodegenerative disease.