Moreover, in ALS patients with GGGGCC (G4C2) expansion mutation in the C9ORF72 gene, nuclear RNA foci formed by (G4C2)n colocalize with paraspeckle proteins such as FUS, highlighting the involvement of paraspeckle in ALS (Bajc Česnik et al., 2019). This evidence concerns the gene FUS and amyotrophic lateral sclerosis.