FUS and amyotrophic lateral sclerosis: ALS mutations in FUS were shown to disrupt axonal transport and general intra-axonal protein synthesis in cultures of Xenopus retinal neurons as well as in mouse sciatic nerve axons in vivo (Murakami et al., 2015; Guo et al., 2017; López-Erauskin et al., 2018), thus highlighting the role of FUS in transport granule dynamics.