Meng et al. demonstrated that m6A-mediated upregulation of LINC00857 promotes the occurrence of pancreatic cancer by functioning as a competing endogenous RNA (ceRNA) for sponging miR-150-5p, leading to overexpressing E2F3 and ultimately promoting tumorigenesis in PC (Meng et al., 2021) Studies had shown that the m6A modification of lncRNA may affect cancer occurrence and development, and lncRNA could act as a competitive endogenous RNA to target m6A modulators, thereby affecting tumor invasion and progression. This evidence concerns the gene E2F3 and cancer.