For instance, overexpression of MALAT-1 could promote the proliferation, migration, and invasion of liver cancer cells by inhibiting the expression of mir-146-5p, thus leading to the recurrence and metastasis of hepatocellular carcinoma (Lai et al., 2012; Li et al., 2017).In addition, Wang et al. demonstrated that UCA1 might act as an endogenous sponge by repressing the expression of FGFR1 and activating an FGFR1/ERK signaling pathway in HCC (Wang et al., 2015). This evidence concerns the gene MALAT1 and hepatocellular carcinoma.