Guanylate binding protein 1 (GBP1) and guanylate binding protein 5 (GBP5) are two member of the GBP family and mediate cellular response to IFNγ in infection and inflammation (Tripal et al., 2007; Britzen-Laurent et al., 2010; Li et al., 2020). This evidence concerns the gene GBP5 and infection.