Recently, strategies related to ACE2 targeting such as decreasing Ang II to decoy receptor (Haschke et al., 2013), blocking ACE2 (Huentelman et al., 2004), enhancing ACE2 shedding (Jia et al., 2009), and facilitating ACE2 internalization (Touret et al., 2020) have been used for the prevention and treatment of COVID-19. The gene discussed is ACE2; the disease is COVID-19.