IgG and IgA autoantibodies against desmocollins (Dsc1, Dsc2 and Dsc3 being Ca2+-dependent cadherins involved in desmosome assembly) have been detected in variable percentage of pemphigus patients (5–60%), according cohorts, Dsc subfamily and the type of pemphigus variant (Dmochowski et al., 1993; Müller et al., 2009; Ishii et al., 2015; Mindorf et al., 2017). The gene discussed is DSC2; the disease is pemphigus.