Another study suggested that the long-lasting response to rituximab in pemphigus could rely on the decrease of Dsg-specific circulating T follicular helper cells, which correlates with a sustained depletion of IgG-switched memory autoreactive B cells, leading to the disappearance of anti-Dsg antibody-secreting cells (Maho-Vaillant et al., 2021). This evidence concerns the gene DSG1 and pemphigus.