Although Dsg-specific autoantibody titre was long-thought to correlate with disease activity in pemphigus (Amagai et al., 1999; Daneshpazhooh et al., 2007; Abasq et al., 2009; Schmidt et al., 2010), more recent studies have detected anti-Dsg3 IgG antibodies in patients who were in clinical remission, suggesting the existence of non-pathogenic Dsg-specific IgG (Belloni-Fortina et al., 2009; Yoshida et al., 2017; Chernyavsky et al., 2019). This evidence concerns the gene DSG1 and pemphigus.