Anti-epiplakin antibodies are especially significant, both clinically and diagnostically as they are thought to be responsible for the occurrence of often-fatal bronchiolitis obliterans, which results from loss of adhesion of the lung epithelium (Tsuchisaka et al., 2016; Tsuchisaka et al., 2016). This evidence concerns the gene EPPK1 and bronchiolitis obliterans syndrome.