Furthermore, it has been reported that in the mouse NASH model, mtDNA released by KCs bound and activated the NLRP3 inflammasome to induce interleukin (IL)-1β and IL-18, triggering proinflammatory responses and resulting in liver fibrosis (Shimada et al., 2012; Pan et al., 2018; Hu et al., 2019). This evidence concerns the gene NLRP3 and Hepatic fibrosis.