The combination of celecoxib and octreotide decreased thioacetamide-induced liver fibrosis in rats by inhibiting the phosphorylation of the extracellular signal-regulated kinase (p-ERK)/HIF-1α/vascular endothelial growth factor (VEGF) pathway (Gao et al., 2016). The gene discussed is HIF1A; the disease is Hepatic fibrosis.